banner (4) (1)

How Does Your Endocannabinoid System Interact With CBD? (Part 2)

The human body, as we can all attest, is a very complicated collection of systems. It’s not very easy to understand one system, let alone how it all works together, unless you’re only scratching the surface of the information. Once you get into the details, things get more and more complex. But your endocannabinoid system doesn’t have to be like that. We’re here to make understanding your body’s inner-working at least a little easier with measured, and sometimes simplified descriptions of how it interacts with stimuli — mostly, in regard to how it interacts with CBD. 

As we discussed last time, we’ve covered the types of endocannabinoid receptors, how those receptors work and what you can classify outside stimulants as versus interior stimulants. This time, we’ll explore just how the system works with CBD and how the receptor that gives you a runner’s high can help you keep your feelings of anxiety under control. Let’s take a look. 

CBD Isn’t The Top Stimuli

Unlike outside stimuli that produce a more responsive reaction out of the receptors that pick up on them, CBD actually creates a rather underwhelming reaction when the endocannabinoid picks up on its presence. In other words, your endocannabinoid receptors don’t prefer CBD to compounds like anandamide or AG-2. In fact, the outside stimulant that your endocannabinoid receptors prefer is, by far, THC. That’s why THC creates such a noticeable effect when you take it (it’s the chemical responsible for creating the high feeling from marijuana products). 

You’ll remember the concept of “allosteric modulation,” that dictates a compound can alter a receptor to be more, or less, responsive in general? Well, CBD is actually a negative modulator for the CB1 receptors in your body. It binds in an unusual fashion to your CB1 receptors and renders them far less effective than they used to be. This is how CBD actually decreases the effectiveness of THC. It permanently modifies the receptors that pick up on the presence of THC and renders them less effective than they used to be. 

The CB2 Receptor 

Your CB2 receptors are the other half of the receptors, or rather the other larger half, of your endocannabinoid system. They’re largely responsible for creating inflammatory reactions throughout the body when it’s stimulated, and told to make certain parts of your body swell. This isn’t necessarily in response to injury, but other inflammatory responses throughout the body. In the same way that CBD interacts with CB1 to make THC less effective, it makes CB2s less effective at sensing when they need to induce an inflammatory response. This is where CBD gets its claim-to-fame for being anti-inflammatory, because it’s actively disabling the inflammatory reaction throughout your body. It should be noted, however, that CBD in general is a rather weak negative modulator for CB1 and CB2 receptors, which is likely why people don’t notice immediate effects when they start a new CBD regimen. 

That being said, where are the claims for how CBD interacts with the whole body coming from if it only is interacting as a minor modulator throughout the endocannabinoid system? It all comes back to the original endocannabinoid compounds, specifically anandamide. 

The Effects Of CBD Are Mostly Indirect

CBD’s Effects on Enzymes

While we’ve largely explained how the endocannabinoid system works, we’ve neglected to mention one crucial part: the enzymes within your system and the transfer of proteins. This directly affects how anandamide, the favored and “default” endocannabinoid, interacts with the system. Essentially, most systems in your body have the basic bare bones of a couple of different components, neurotransmitters to let your brain know what’s occurring, receptors to make something occur and enzymes that act as managers over the whole process. The main enzyme that governs the operations of the endocannabinoid is called the fatty acid amide hydrolase or FAAH. This enzyme is responsible for breaking down anandamide. CBD muffles the ability of your FAAH enzymes, which leads to an increase in the amount of anandamide in your system. This increases the results of anandamide in the body. 

CBD’s Effects on Proteins 

There’s a primary protein in your endocannabinoid system at all times by the name of fatty acid-binding protein, or FABP for short. They’re often responsible for acting as binders to the synapse within anandamide. CBD intercepts those, and gets broken down instead of the anandamide compound already present in your system. This allows for more anandamide to linger in your system on top of CBD’s interactions with the enzyme mentioned above. In fact, slowing down enzymes that act by breaking down feel good chemicals is how must drugs and psychoactive substances work. 

How Does This Affect My Body?

Each of these indirect effects of CBD produce a certain sort of unplanned reaction in the body. For example, CB1 receptors being activated sometimes results in pain, thus when CBD blocks these receptors, it creates an analgesic effect like a pain-killer would. It’s ability to cancel out the effects of THC in this same type of interaction with the CB1 receptors could point to sedative and relaxing effects of CBD. The interactions CBD has with the CB2 receptors, which trigger inflammation, give it the anti-inflammatory properties and the decreased metabolization of anandamide could cause effects like reduced anxiety and reaping other benefits of the anandamide compound. 

This all factors in to create the whole body holistic health effects that CBD provides folks who use it. If you think you may be a good candidate for taking advantage of one of the many effects of CBD on the body and the endocannabinoid system, check out our stock. We provide exceptional quality CBD to a variety of folks by vetting and testing the quality of their products. Shop our selection of CBD oil and more now.