CBD and The Endocannabinoid System

How Does CBD Actually Effect Your Body?

It’s no surprise that Cannabidiol or CBD is taking the world by storm. So many people have reported that CBD has genuinely helped them with a multitude of issues, both mentally and physically. From reduced anxiety and insomnia to improved movement and less joint pain, CBD has become a very widely used supplement. Due to its popularity, it’s vital that you understand exactly how CBD works within your body. They say that “knowledge is power” and that is especially true when it comes to the endocannabinoid system and CBD.

At Hemp Market Exchange, we’re your number one resource when it comes to all things hemp and CBD. Not only do we offer our customers education on the topic but we also offer the highest quality CBD products. We even give hard working hemp producers a place to connect and sell their own goods. As hemp experts, we understand the extreme supply and demand for these types of products — and we’re giving buyers and sellers a safe place to meet. When you think Hemp and CBD, think Hemp Market Exchange.

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What is the Endocannabinoid System?

The human body is an incredible system and every part of your body works together in perfect harmony. The human body is also a very complex system which requires intricate knowledge about how it works. You could truly spend copious amounts of time researching the endocannabinoid system, but we’re here to give you the low down on how this system works, specifically in regards to CBD.

Cannabinoids are defined as the substances that interact with our endocannabinoid system. There are two types of receptors of the endocannabinoid system called CB1 and CB2. These receptors can be found all over the body, with specific types being more dominant in some areas over others. The areas where these receptors are largely found tend to be the places in the body where cannabinoids produce the most noticeable effects.

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The Receptors

It’s best to think of the receptors as a lock. Each receptor is designed to be specifically opened, or activated, by another specific compound (or key, since we’re going with the lock metaphor). There are a variety of different keys that will open these locks. The most common keys are the endocannabinoids in the body that are already created. These keys can be called AG-2 and anandamide. Both of these receptors create the feelings that can be closely associated with a “runner's high” and the sleepy, content feelings of satisfaction that you may get from any of your favorite activities. These cannabinoids your system synthesizes can activate these receptors and so can outside sourced cannabinoids like CBD.

You may have seen interactions like these with outside stimulants that create a bigger response like coffee, alcohol, and other opiates. Similarly, these substances imitate a chemical that is already present in your body and create the more noticeable response. This is because the outside receptors interact better with these receptors that the ones that are already present in your body. This is also why everyone may have a different experience while taking CBD. Just like everyone may act differently while under the influence of alcohol or opiates, not everyone's experience with CBD is the same. While many people have expressed feelings of calmness and serenity, it may not be the same for everyone.

Activating the Receptors

Whenever a compound is interacting with a receptor anywhere in the body that’s not just specific to the endocannabinoid system, there are steps that create an effective activation of that specific receptor. Starting out, the compound which is being activated binds to the receptor or the joint between the two nerve cells. This can help the receptor transmit the signal throughout the body from the stimulation.

Receptors are also activated through an interaction called “allosteric modulation.” This name comes from representation of the process when a substance can start to modify the way in which the receptor interacts and works directly with the body. This interaction simply alters this state.

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So How Does All This Work With CBD?

As opposed to outside stimuli, which produce more of a responsive reaction out of the receptors that pick up on them, CBD creates more of an underwhelming reaction when the endocannabinoids pick up on it. Basically, your endocannabinoid receptors don’t prefer CBD compounds like anandamide of AG-2. The outside stimulant that your endocannabinoid receptors prefer is THC. This is why THC creates that very noticeable “stoned” effect when you consume it. 

Looking back to the concept of “allosteric modulation,” this dictates the compound that can alter a receptor to me more or less responsive. Looking at CBD, CBD is actually a negative modulator for the CB1 receptors in your body. They bind to your CB1 receptors and renders them far less effective than they used to be. This is why CBD actually decreases the effectiveness of THC. It permanently modifies the receptors which pick up on the presence of THC, making them less effective than they used to be.

You also have CB2 receptors and these are the other half of the receptors and the larger half of the endocannabinoid system. These are largely responsible for creating inflammatory reactions throughout the body when its stimulated making parts of your body swell. While this isn’t specific to an injury response, but to the other inflammatory responses throughout the body. Just as CBD interacts with CB1 to make THC less effective, it makes CB2s less effective at sensing when they need to induce an inflammatory response, which is why CBD is claimed to have anti-inflammatory properties and why people have reported a reduction of pain when using it.

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How Does This And CBD Affect My Body?

Each of the indirect effects of CBD produce a certain reaction, which may be unplanned, but are a reaction nonetheless. For example, CB1 receptors are activated in response to pain, so when CBD blocks these receptors, people may report a feeling of reduced pain. 

We know that we’ve just given you an intense amount of information regarding the human body, the endocannabinoid system, and CBD. For more information and an even deeper analysis, check out our blog page

Remember that CBD should not be used as a cure for anything and that there is still immense amounts of ongoing research that is being conducted. You should always consult a doctor or physician before using CBD. While many people have a similar experience, everyone is different and that you should always start with a low dosage of anything.

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